Monday, 25 February 2013

More on TPP, and RCEP, and Japan and China and South Korea


Paul Sracic and Richard Katz have kindly corrected my error regarding the 90-day prior notification to?not approval from?Congress, while reminding me that it is no longer required by law since trade promotion (fast-track) authority (TPA) expired in 2007 but the Obama administration is respecting it any way since it will be seeking fast-track authority when it seeks ratification. Thanks. It?s a slippery road from a technical error to rumormongering if I don?t check the facts with an authoritative source. And it?s unporofessional. Paul?s substantive point, actually, is that that TPA will be harder to secure than TPP ratification itself because it can be filibustered while ratification under TPA cannot. Paul also mentioned that the Regional Comprehensive Economic Partnership (RCEP) pushed by ASEAN is ?portrayed as a competitor or threat to TPP.? in the US media. Let?s hope that he amplifies that point in an op-ed or something of the sort. In the meantime, the following was my more general take on the proliferation of FTAs. Now that everyone?and I mean literally everyone?agrees that the Doha Round is dead, FTA is the name of the game, and there's a lot of (positive) competition going on among the various efforts. The US and EU plant a kicking tee for an FTA? All the more reason for the Abe administration to finesse its way into the TPP negotiations, which in turn is surely pushing China and South Korea to move forward on the trilateral FTA with Japan.

If throwing your hat into the TPP negotiations is enough to help China and South Korea to put domestically combustible history and sovereignty issues aside to negotiate with Japan on a prospective FTA, then it should be more than enough to?convince them to move forward with RCEP, a development for which the rest of the prospective RCEP members will offer their unconditional support for commercial, geoeconomic, and geopolitical reasons.

Source: http://son-of-gadfly-on-the-wall.blogspot.com/2013/02/more-on-tpp-and-rcep-and-japan-and.html

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Sunday, 24 February 2013

Reprogramming cells to fight diabetes

Feb. 22, 2013 ? For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The "reprogramming" of related alpha cells into beta cells may one day offer a novel and complementary approach for treating type 2 diabetes. Treating human and mouse cells with compounds that modify cell nuclear material called chromatin induced the expression of beta cell genes in alpha cells, according to a new study that appears online in the Journal of Clinical Investigation.

"This would be a win-win situation for diabetics -- they would have more insulin-producing beta cells and there would be fewer glucagon-producing alpha cells," says lead author Klaus H. Kaestner, Ph.D., professor of Genetics and member of the Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania. Type 2 diabetics not only lack insulin, but they also produce too much glucagon.

Both type 1 and type 2 diabetes are caused by insufficient numbers of insulin-producing beta cells. In theory, transplantation of healthy beta cells -- for type 1 diabetics in combination with immunosuppression to control autoimmunity -- should halt the disease, yet researchers have not yet been able to generate these cells in the lab at high efficiency, whether from embryonic stem cells or by reprogramming mature cell types.

Alpha cells are another type of endocrine cell in the pancreas. They are responsible for synthesizing and secreting the peptide hormone glucagon, which elevates glucose levels in the blood.

"We treated human islet cells with a chemical that inhibits a protein that puts methyl chemical groups on histones, which -- among many other effects -- leads to removal of some histone modifications that affect gene expression," says Kaestner. "We then found a high frequency of alpha cells that expressed beta-cell markers, and even produced some insulin, after drug treatment.

Histones are protein complexes around which DNA strands are wrapped in a cell's nucleus.

The team discovered that many genes in alpha cells are marked by both activating- and repressing-histone modifications. This included many genes important in beta-cell function. In one state, when a certain gene is turned off, the gene can be readily activated by removing a modification that represses the histone.

"To some extent human alpha cells appear to be in a 'plastic' epigenetic state," explains Kaestner. "We reasoned we might use that to reprogram alpha cells towards the beta-cell phenotype to produce these much-needed insulin-producing cells."

Co-authors are Nuria C. Bramswig, Logan Everett, Jonathan Schug, Chengyang Liu, Yanping Luo, and Ali Naji, all from Penn, and Markus Grompe, Craig Dorrell, and Philip R. Streeter from the Oregon Health & Science University. The Oregon group developed a panel of human endocrine cell type-specific antibodies for cell sorting.

The research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK070430, U42 RR006042, U01DK089529, R01DK088383, U01DK089569) and by the Beckman Research Center/NIDDK/Integrated Islet Distribution Program (10028044).

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The above story is reprinted from materials provided by Perelman School of Medicine at the University of Pennsylvania.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nuria C. Bramswig, Logan J. Everett, Jonathan Schug, Craig Dorrell, Chengyang Liu, Yanping Luo, Philip R. Streeter, Ali Naji, Markus Grompe, Klaus H. Kaestner. Epigenomic plasticity enables human pancreatic ? to ? cell reprogramming. Journal of Clinical Investigation, 2013; DOI: 10.1172/JCI66514

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/YsxoP3tN1kI/130223111356.htm

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Saturday, 23 February 2013

Israeli Oscar contenders force citizens to confront uncomfortable questions

Two Israeli documentary films nominated for Oscars, 'The Gatekeepers' and '5 Broken Cameras,' raise difficult questions about the Israeli occupation of the Palestinian?territories.

By Chelsea Sheasley,?Correspondent / February 23, 2013

A poster for the Oscar-nominated documentary '5 Broken Cameras' is displayed at a theatre in the West Bank city of Ramallah, last month.

Mohamad Torokman/Reuters

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A former spy chief is making gripping statements about the Israeli-Palestinian conflict, but at Jerusalem?s chic Cinamatheque, two university students can?t keep their eyes on the screen. One sends text messages and checks Facebook; the other shifts uneasily.

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?I felt uncomfortable in my chair,? says one of them, Shay Amiran, a former combat soldier, after the screening of Oscar-nominated ?The Gatekeepers.? He especially bristled at a comparison between Israel and Nazi Germany during World War II.

?The Gatekeepers,? which interviews six former heads of Israel?s Shin Bet intelligence agency, along with ?5 Broken Cameras,? which captures a Palestinian family?s life amid protests against construction of Israel?s separation wall, are the first Israeli-funded films to receive Academy Award nominations for best documentary since 1975. While winning international acclaim, the movies are riling people on both sides of the political aisle in Israel ? from those who see them as government-funded ?self-flagellation? to those who see the movies as raising crucial issues that the Israeli public and government are unwilling to address.

?It?s an incredible achievement for the Israeli film industry,? says Amy Kronish, an Israeli film critic. ?Both of these films deal with issues that are not being grappled or tackled by the Israelis at this time.?

While the movies were initially pigeonholed as boutique films that would draw only a fraction of Israelis, ?The Gatekeepers? recently became the first documentary to be shown in commercial theaters in Israel and is the second-highest grossing Israeli film of the year.

The overriding message of the films, which both received indirect government funding through subsidies to the Israeli film industry, is that the status quo in the Israeli-Palestinian conflict is unsustainable. What sets them apart from the many other films on the topic is the rarity of the voices that share the message: Israelis from the heart of the defense establishment in ?The Gatekeepers? and a young Palestinian boy in ?5 Broken Cameras.?

In the opening scene of ?5 Broken Cameras,? Palestinian Emad Burnat, who shot the footage and co-directed the movie, describes the birth of his children as symbolizing different phases of the conflict. His first son was born, he says, ?in the optimism of Oslo,? his second at the start of the second intifada. His third son, Gibreel, was born in 2005 at the same time his village began protests against construction of the Israeli separation barrier through their farmland.

The movie captures Gibreel?s first words: ?wall? and ?soldiers.?

In ?The Gatekeepers? all six former heads of Shin Bet call, in varying degrees, for collaboration with Palestinians. Sitting calmly in suspenders or polo shirts, the former chiefs reflect on the moral dilemmas they faced, such as deciding whether to drop a one-ton bomb on a Gaza militant if it meant others in the neighborhood would be killed.

The movie portrays the ex-chiefs as questioning whether they succeeded at a tactical level, but lacked a broader strategy to bring lasting peace.

?We?re winning all the battles,? says Ami Ayalon, Shin Bet chief from 1996 to 2000, in the movie. ?And we?re losing the war.?

'Occupation' should end

The directors and their supporters say that Israel?s policies toward the Palestinian territories are ultimately undermining the longevity of the Jewish state.

Dror Moreh, director of ?The Gatekeepers,? says he intended his film for Israelis plus an international audience that would exert pressure on the Israeli government.

?I wanted this movie to change things, to stir up debate, to stir up beliefs and to challenge people who believe in one thing,? he says. ?The message [is] that the occupation of the West Bank is bad for the safety and security of Israel.?

Guy Davidi, the Israeli co-director of ?5 Broken Cameras,? also believes pressure should come from Israeli society and abroad if government policies are to change.

?I don?t believe that change comes from just inside, or just outside,? he says. ?It?s natural to want pressure from other countries to stop occupation because from my point of view stopping occupation is something good for Israel.?

For some Israelis, however, the films present an incomplete portrait of a complex conflict. Some see them as part of a broader asymmetry, in which the international community focuses disproportionately on Israeli missteps without regard to transgressions by Palestinians ? like in the Boycott, Divestment, and Sanctions (BDS) campaign, which seeks to penalize Israel financially and isolate it internationally for its policies toward the Palestinian territories.

?While the films are well-made, we can suspect that their nomination does not stem from international recognition of the Jewish state?s filmmaking abilities, but from an international obsession with shaming it,? wrote opinion columnist Hagai Segal in Israel?s YNet News.

There?s also a sense that those abroad are overly critical of Israel without understanding the security concerns of its citizens, many of whom have had to contend with violence in their daily lives ? whether through army service, suicide bombings, or rocket attacks.

Indeed, security is of top concern for Mr. Amiran and his friend Hila, who went to the Jerusalem Cinamatheque screening of ?The Gatekeepers? out of curiosity from the Oscar buzz. Their view is shaped by personal loss and a distrust of Palestinian desire for peace, which they believe was discredited by the outbreak of the second intifada after a peace offer by former Prime Minister Ehud Barak.

?If you want to talk about morality, you have no justification for killing kids, teenagers,? says Hila, whose friend was killed in 2001 in an attack on a cafe when she was 15.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/z89NX0nPRg4/Israeli-Oscar-contenders-force-citizens-to-confront-uncomfortable-questions

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iPhone Siri wannabe apps

Apple?s Siri voice recognition ushered in a whole new era in smart-phone technology. Now downloadable apps are trying to get in on the conversation. Consumer Reports just took a look to see how two of the leading free apps?Robin and Speaktoit?stack up.

Speaktoit is available on several platforms, including iPhone; Robin is exclusively for Android phones. Consumer Reports asked each similar questions. Both Robin and Speaktoit do well with some requests. But they struggle with other questions. Siri, on the other hand, has no problem with these requests.

Consumer Reports says Siri remains the voice-recognition standout. It?s hardwired into your iPhone and has access to much more of your personal information. And that?s an edge that none of the other apps can compete with yet.

If you don?t have an iPhone with Siri, Consumer Reports says downloading a free app gives you at least some voice-recognition capability. Speaktoit seems to be one of the best so far. It works on both the iPhone and Androids.

Source: http://www.news4jax.com/consumer-news/consumer-reports/iPhone-Siri-wannabe-apps/-/1934720/19018808/-/15rgaqh/-/index.html

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Catch a wave at this Calif. home

9 Arroyo Quemada Ln, Goleta, Calif.
For sale: $2.45 milliom

Normally you wouldn't be able to hear the sound of waves in a home perched 60 feet above the beach, but the Wave House in Goleta was engineered to not only look like a wave but to capture the sound as well.

"You hear the waves pounding even though they are quite a ways away," said Montecito listing agent Steven Richardson of Coldwell Banker. "It's part of the treats offered up."

There are several other design "treats" revealed throughout the home ? from the spectacular views of the ocean to the curved exterior. The residence was reportedly designed by Michael Carmichael, who was given free rein to engineer the one-of-kind home.

The two-bed, one-bath dome includes an office, large kitchen and living room framed by spiraling glass windows facing the water.

"It's hard to put into words the sensation that you get when you're inside the property and around the grounds," said Richardson. "Most of the inside of the house draws the outside in. From the sounds and the views -- [they] all blend and mix around you."

A guest tower provides additional whimsy. Measuring 30-feet high, the tower is topped by an ocean-facing observation deck. At the edge of the property, another deck and hot tub also provide an unobstructed view of the water.

Newly constructed stairs lead to the beach below. The California home is also situated beyond a gated street, ensuring privacy.

And, as you could guess, Richardson said the sunsets are incredible.

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Source: http://www.nbcnews.com/business/catch-wave-calif-home-1C8417255

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Native Instruments announces Traktor DJ for iPad, brings the mix to iOS (video)

Native Instruments Releases TRAKTOR DJ App Exclusively for iPad

Berlin, February 21, 2013 ? Native Instruments today released TRAKTOR DJ ? a unique, hands-on DJ app built from the ground up for iPad aimed at DJs of all levels from novices to touring professionals. Created by the same team behind the top-selling TRAKTOR brand, TRAKTOR DJ strikes a balance between instant, fun usability and advanced, professional features. TRAKTOR DJ allows users to intuitively access their music in a whole new way while also complementing the TRAKTOR family through bi-directional content synchronization with TRAKTOR PRO software.

TRAKTOR DJ puts the waveform in the center of user interaction, featuring two decks, each with dedicated 3-band EQ and filter sections, as well as 8 proven TRAKTOR effects. Utilizing familiar iOS Multi-Touch gestures like pinch and swipe, TRAKTOR DJ brings a professional quality mixing experience to iPad ? equally suited to full performance or on-the-go set preparation. Users can intuitively manipulate waveforms by touch, "grabbing" their music with two fingers to instantly set a loop, perform scratches, mark cue points for live re-editing, and scrub, browse or navigate through tracks ? the key functions of the TRAKTOR PRO 2 software, re-designed for touchscreen interaction.

TRAKTOR DJ introduces the completely new Freeze Mode, which lets users slice up a waveform into playable parts for on-the-fly remixing and entirely new musical performances. The app also allows users to create beat grids in real time, intuitively mapping out a song's groove without having to stop the music. DJs are encouraged to discover the full extent of TRAKTOR DJ's capabilities at their own speed via the Notification Center, which tracks the user's progress through the app's features and unobtrusively offers tips, tricks, and techniques from within the app.

With over a decade of technological refinement through the evolution of TRAKTOR, TRAKTOR DJ's automatic tempo detection and sync engine are now accompanied by precise downbeat analysis. This makes beat mixing completely straightforward and frees users to creatively interact with their music via the touch interface. Full iTunes music library integration of TRAKTOR DJ means DJs can easily search their library for the next track. Unique to TRAKTOR DJ, the app introduces a recommendation engine that uses advanced tempo, key, and timbre detection algorithms. TRAKTOR DJ recommends compatible tracks from your iTunes library with the same tempo and harmonic structure in real time, facilitating smooth and ear-pleasing mixes for users of all levels. Both the advanced downbeat and key detection features will also be available to TRAKTOR PRO customers with a dedicated 2.6.1 software update.

Complementing the existing range of TRAKTOR products, TRAKTOR DJ bi-directionally syncs track settings and properties with TRAKTOR PRO 2. This gives DJs an ideal workflow for planning a set while on the move. Users can also transfer all their stored work in TRAKTOR PRO directly to TRAKTOR DJ ? all beat grids, cue points, loops and BPM counts seamlessly transfer between iPad and TRAKTOR PRO 2 and back via a free Dropbox account.

Additionally, because of the powerful Core Audio engine built into iOS, TRAKTOR DJ also offers ultra-low latency playback, manipulation and recording while also supporting professional class compliant hardware audio interfaces, such as the TRAKTOR AUDIO 6 and 10, something currently not possible on any other mobile platform. DJs can connect these and other devices to their iPad using the iPad Camera Connection Kit? for optimum audio quality and pre-listen and cue functionality, or to a splitter cable with dedicated cue and master controls. All of this allows TRAKTOR DJ users to easily record their mixes live on their iPad, or pump their music out to the house in the highest quality possible.

A video of visionary DJ Richie Hawtin's first day with TRAKTOR DJ, in which he prepares a set and performs live with the app at BPM festival in Mexico, is available on YouTube at:
http://youtu.be/ScjJiGYawuM

The TRAKTOR DJ App is available for $ 19.99 / 17.99 ? / 1700 ? from the App Store on iPad or at www.AppStore.com/TRAKTORDJ. TRAKTOR DJ officially supports iPad with Retina display, iPad mini and iPad 2, running iOS 6 and above.

Source: http://www.engadget.com/2013/02/21/traktor-dj-ipad-app/

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